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1

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

Klein, Ludger, Kyewski, Bruno, Allen, Paul M., Hogquist, Kristin A.

Journal:

Nature Reviews Immunology

Year:

2014

Language:

english

File:

PDF, 1.76 MB

english, 2014

2

The Protagonist, My Facebook Friend: How Cross-Media Extensions Are Changing the Concept of Parasocial Interaction.

Kyewski, Elias, Szczuka, Jessica M., Krämer, Nicole C.

Journal:

Psychology of Popular Media Culture

Year:

2016

Language:

english

File:

PDF, 135 KB

english, 2016

3

To gamify or not to gamify? An experimental field study of the influence of badges on motivation, activity, and performance in an online learning course

Kyewski, Elias, Krämer, Nicole C.

Journal:

Computers & Education

Year:

2018

Language:

english

File:

PDF, 335 KB

english, 2018

4

Conflicts of interest: The responsibility of the authors and editors of the International Journal of Cancer

Harald zur Hausen, Helmut Bartsch, Norbert Fusenig, Magnus von Knebel Doeberitz, Bruno Kyewski, Peter Lichter, Anthony Miller

Journal:

International Journal of Cancer

Year:

2006

Language:

english

File:

PDF, 35 KB

english, 2006

5

[Current Topics in Microbiology and Immunology] CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential Volume 293 ||

Compans, R.W., Cooper, M.D., Honjo, T., Koprowski, H., Melchers, F., Oldstone, M.B.A., Olsnes, S., Potter, M., Vogt, P.K., Wagner, H., Kyewski, Bruno, Suri-Payer, Elisabeth

Year:

2005

Language:

english

File:

PDF, 3.15 MB

english, 2005

6

Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance

Ludger Klein, Bernd Roettinger, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

2001

Language:

english

File:

PDF, 240 KB

english, 2001

7

Über den magnetischen Skineffekt in ferromagnetischen Kreiszylindern bei schwachen und starken Wechselfeldern

Journal:

Annalen der Physik

Year:

1936

Language:

german

File:

PDF, 556 KB

german, 1936

8

Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice

Short Paper, Kazimir Dux, Robert V. Rouse, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

1986

Language:

english

File:

PDF, 425 KB

english, 1986

9

Phenotype of stromal cell-associated thymocytes in situ is compatible with selection of the T cell repertoire at an “immature” stage of thymic T cell differentiation

Bruno A. Kyewski, Frank Momburg, Volker Schirrmacher

Journal:

European Journal of Immunology

Year:

1987

Language:

english

File:

PDF, 752 KB

english, 1987

10

CD4+ helper T cells are required for resistance to a highly metastatic murine tumor

Hans-Jörg Schild, Bruno Kyewski, Paul von Hoegen, Volker Schirrmacher

Journal:

European Journal of Immunology

Year:

1987

Language:

english

File:

PDF, 426 KB

english, 1987

11

Antibodies against the T cell receptor/CD3 complex interfere with distinct intra-thymic cell-cell interactions in vivo: correlation with arrest of T cell differentiation

Bruno A. Kyewski, Volker Schirrmacher, James P. Allison

Journal:

European Journal of Immunology

Year:

1989

Language:

english

File:

PDF, 1.09 MB

english, 1989

12

The effects of anti-CD2 antibodies on the differentiation of mouse thymocytes

Bruno A. Kyewski, Eric J. Jenkinson, Rosetta Kingston, Peter Altevogt, Michael J. Owen, John J. T. Owen

Journal:

European Journal of Immunology

Year:

1989

Language:

english

File:

PDF, 349 KB

english, 1989

13

Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes

Peter Altevogt, Marion Michaelis, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

1989

Language:

english

File:

PDF, 1.45 MB

english, 1989

14

Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cells

Hanspeter Pircher, Karin Brduscha, Ulrich Steinhoff, Michiyuki Kasai, Toshiaki Mizuochi, Rolf M. Zinkernagel, Hans Hengartner, Bruno Kyewski, Klaus-Peter Müller

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 640 KB

english, 1993

15

T cell receptor targeting to thymic cortical epithelial cells in vivo induces survival, activation and differentiation of immature thymocytes

Klaus-Peter Müller, Bruno A. Kyewski

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 1.59 MB

english, 1993

16

Half-life of antigen/major histocompatibility complex class II complexes in vivo: intra- and interorgan variations

Klaus-Peter Müller, Jochen Schumacher, Bruno A. Kyewski

Journal:

European Journal of Immunology

Year:

1993

Language:

english

File:

PDF, 597 KB

english, 1993

17

Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II

Klaus-Peter Müller, Bruno A. Kyewski

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 811 KB

english, 1995

18

Clonal deletion of major histocompatibility complex class I-restricted CD4+CD8+ thymocytes in vitro is independent of the CD95 (APO-1/Fas) ligand

Klaus-Peter Müller, Sara M. Mariani, Bernd Matiba, Bruno Kyewski, Peter H. Krammer

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 453 KB

english, 1995

19

Tolerance and immunity to the inducible self antigen C-reactive protein in transgenic mice

Thomas C. Klein, Rainer Döffinger, Mark B. Pepys, Ulrich Rüther, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

1995

Language:

english

File:

PDF, 784 KB

english, 1995

20

Two separable T cell receptor signals reconstitute positive selection of CD4 lineage T cells in vivo

Steffen Schmitt, Klaus-Peter Müller, Bruno A. Kyewski

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 634 KB

english, 1997

21

A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production

Susanne Hartmann, Bruno Kyewski, Bettina Sonnenburg, Richard Lucius

Journal:

European Journal of Immunology

Year:

1997

Language:

english

File:

PDF, 872 KB

english, 1997

22

CREB function is required for normal thymic cellularity and post-irradiation recovery

Sven Baumann, Bruno Kyewski, Susanne C. Bleckmann, Erich Greiner, Dorothea Rudolph, Wolfgang Schmid, Robert G. Ramsay, Peter H. Krammer, Günther Schütz, Theo Mantamadiotis

Journal:

European Journal of Immunology

Year:

2004

Language:

english

File:

PDF, 329 KB

english, 2004

23

Highly variable expression of tissue-restricted self-antigens in human thymus: Implications for self-tolerance and autoimmunity

Richard Taubert, Jochen Schwendemann, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 283 KB

english, 2007

24

Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells

Jana Gäbler, Janna Arnold, Bruno Kyewski

Journal:

European Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 522 KB

english, 2007

25

Obligation for cell line authentication: Appeal for concerted action

Peter Lichter, Heike Allgayer, Helmut Bartsch, Norbert Fusenig, Kari Hemminki, Magnus von Knebel Doeberitz, Bruno Kyewski, Anthony B. Miller, Harald zur Hausen

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 48 KB

english, 2010

26

Editorial

Bruno Kyewski, Pedro Romero

Journal:

International Journal of Cancer

Year:

2010

Language:

english

File:

PDF, 59 KB

english, 2010

27

Thymic nurse cells: possible sites of T-cell selection

Bruno A. Kyewski

Journal:

Immunology Today

Year:

1986

Language:

english

File:

PDF, 1.14 MB

english, 1986

28

Taking the thymus to pieces

Bruno Kyewski, Thomas Hünig

Journal:

Immunology Today

Year:

1992

Language:

english

File:

PDF, 353 KB

english, 1992

29

Transcription factors that control development of the thymic microenvironment

Thomas Boehm, Michael Nehls, Bruno Kyewski

Journal:

Immunology Today

Year:

1995

Language:

english

File:

PDF, 381 KB

english, 1995

30

Regulating self-tolerance by deregulating gene expression

Jörn Gotter, Bruno Kyewski

Journal:

Current Opinion in Immunology

Year:

2004

Language:

english

File:

PDF, 102 KB

english, 2004

31

How thymic antigen presenting cells sample the body's self-antigens

Jens Derbinski, Bruno Kyewski

Journal:

Current Opinion in Immunology

Year:

2010

Language:

english

File:

PDF, 351 KB

english, 2010

32

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues

Thorsten Klamp, Ugur Sahin, Bruno Kyewski, Jochen Schwendemann, Karl Dhaene, Özlem Türeci

Journal:

Immunology Letters

Year:

2006

Language:

english

File:

PDF, 273 KB

english, 2006

33

Two separable TCR-signaling steps reconstitute positive selection in vivo

S. Schmitt, B.A. Kyewski

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 187 KB

english, 1997

34

Self-antigen presentation by thymic stromal cells: a subtle division of labor

Ludger Klein, Bruno Kyewski

Journal:

Current Opinion in Immunology

Year:

2000

Language:

english

File:

PDF, 139 KB

english, 2000

35

A SNP in intron 1 of TSHR controls its thymic expression and susceptibility to Graves’ disease suggesting central tolerance failure in pathogenesis

Maria del Pilar Armengol, Rosa Faner, Lars-Olivier Tykocinski, Anna Lucas-Martin, Marta Ruiz-Riol, Manel Juan, Bruno Kyewski, Ricardo Pujol-Borrell, Roger Colobran

Journal:

Journal of Translational Medicine

Year:

2011

Language:

english

File:

PDF, 82 KB

english, 2011

36

Modern trends in human leukemia VI wilsede, June 17–21, 1984

G. Heil, B. Kyewski, A. Whetton

Journal:

Annals of Hematology

Year:

1985

Language:

english

File:

PDF, 522 KB

english, 1985

37

Auftrieb eines Flügels, der ein Gebiet erhöhter Geschwindigkeit schneidet

B. Kyewski, F. Vandrey

Journal:

Archive of Applied Mechanics

Year:

1939

Language:

german

File:

PDF, 678 KB

german, 1939

38

Promiscuous expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?

Ludger Klein, Bruno Kyewski

Journal:

Journal of Molecular Medicine

Year:

2000

Language:

english

File:

PDF, 187 KB

english, 2000

39

Central tolerance due to ectopic self antigen expression in the thymus pre-empts variable and leaky peripheral tolerance

L. Klein, U. Rüther, B.A. Kyewski

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 185 KB

english, 1997

40

Intrathymic presentation of circulating non-major histocompatibility complex antigens

Kyewski, B. A., Fathman, C. G., Kaplan, H. S.

Journal:

Year:

1984

File:

PDF, 494 KB

1984

41

10.1038/71540

Kyewski, Bruno, Klein, Ludger, Klugmann, Matthias, Nave, Klaus-Armin, Tuohy, V K

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 217 KB

english, 2000

42

Response to 'Lymphoid organs contain diverse cells expressing self-molecules'

Kyewski, Bruno, Derbinski, Jens, Schulte, Antje, Klein, Ludger

Journal:

Nature Immunology

Year:

2002

Language:

english

File:

PDF, 27 KB

english, 2002

43

10.1038/ni723

Derbinski, Jens, Schulte, Antje, Kyewski, Bruno, Klein, Ludger

Journal:

Nature Immunology

Year:

2001

Language:

english

File:

PDF, 2.07 MB

english, 2001

44

Bone marrow as a priming site for T-cell responses to blood-borne antigen

Feuerer, Markus, Beckhove, Philipp, Garbi, Natalio, Mahnke, Yolanda, Limmer, Andreas, Hommel, Mirja, Hämmerling, Günter J, Kyewski, Bruno, Hamann, Alf, Umansky, Viktor

Journal:

Nature Medicine

Year:

2003

Language:

english

File:

PDF, 2.65 MB

english, 2003

45

Self-representation in the thymus: an extended view

Kyewski, Bruno, Derbinski, Jens

Journal:

Nature Reviews Immunology

Year:

2004

Language:

english

File:

PDF, 280 KB

english, 2004

46

Antigen presentation in the thymus for positive selection and central tolerance induction

Klein, Ludger, Hinterberger, Maria, Wirnsberger, Gerald, Kyewski, Bruno

Journal:

Nature Reviews Immunology

Year:

2009

Language:

english

File:

PDF, 600 KB

english, 2009

47

How Promiscuity Promotes Tolerance: The Case of Myasthenia Gravis

Bruno Kyewski, Richard Taubert

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 195 KB

english, 2008

48

The Thymus Medulla Slowly Yields Its Secrets

Lars-Oliver Tykocinski, Anna Sinemus, Bruno Kyewski

Journal:

Annals of the New York Academy of Sciences

Year:

2008

Language:

english

File:

PDF, 368 KB

english, 2008

49

OR.23. Transcriptional Control of CHRNA1 Gene in Thymus By a Promoter SNP Associated with Onset of Autoimmune Myasthenia Gravis

Matthieu Giraud, Richard Taubert, Bruno Kyewski, Claire Vandiedonck, Matthieu Levi-Strauss, Franco Pagani, Francisco Baralle, Bruno Eymard, Christine Tranchant, Philippe Gajdos, Angela Vincent, Nick W

Journal:

Clinical Immunology

Year:

2006

Language:

english

File:

PDF, 41 KB

english, 2006

50

DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues

Vivian Kont, Astrid Murumägi, Lars-Oliver Tykocinski, Sarah A. Kinkel, Kylie E. Webster, Kai Kisand, Liina Tserel, Maire Pihlap, Philipp Ströbel, Hamish S. Scott, Alexander Marx, Bruno Kyewski, Pärt P

Journal:

Molecular Immunology

Year:

2011

Language:

english

File:

PDF, 1.55 MB

english, 2011